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Angioimmunoblastic T-Cell Lymphoma
Lessons From the Friday Unknowns
Lymph node (left groin), excision (270-SP-22–0003142 B; 4/27/2022):
ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA (SEE COMMENT)
Histologic sections of the specimen designated left groin show slightly larger tissue fragments. The largest tissue fragment fragments shows some lymph node architecture that appears to be completely replaced by an atypical infiltrate suggestive of angioimmunoblastic T-cell lymphoma.
![](https://miro.medium.com/v2/resize:fit:700/1*vRMCSJMZp6sefzEWycvADg.png)
![](https://miro.medium.com/v2/resize:fit:700/1*KICVnW2BcGFgBkBCYc_Dog.png)
![](https://miro.medium.com/v2/resize:fit:700/1*PLO6mFNnrj8uXc4qOKrphQ.png)
The infiltrate is composed of small lymphoid cells with clear cytoplasm and HEV proliferation. Eosinophils and plasma cells are also present in the background.
![](https://miro.medium.com/v2/resize:fit:700/1*OjZ3XRpXXp9O7zFwEC12MQ.png)
Flow cytometry immunophenotypic studies showed 12.5% CD10-positive T cells. The T-cells were also positive for CD2, CD3 (dim), CD4, CD7 (dim), CD26, CD45 and monotypic TRBC1.
Clonal TRG rearrangement detected by PCR analysis.
In summary, the morphologic findings are highly suggestive of angioimmunoblastic T-cell lymphoma in both the left axillary and groin specimens. Furthermore this impression is supported by the results of flow cytometry immunophenotyping and molecular studies.
Link to digital slides: bit.ly/3lKxdQw | Case 4