Classic Hodgkin Lymphoma, Mixed Cellularty, EBV+ Arising in Immune Defficiency/ Dysregulation
Lessons From the Friday Unknowns
The patient has a history of HIV infection.
Histological sections show several needle shaped lymph node, which is involved by lymphoma. The lymphoma is composed of atypical large cells, morphologically consistent with Hodgkin cells in a background with rich histiocytes, eosinophils, and small lymphocytes. Mild sclerosis is noted.
Immunohistochemical studies demonstrate that the lymphoma cells are positive for CD15, CD30, PAX 5 (weak in a subset), MUM1, and PD–L1. The lymphoma cells are negative for CD20 and CD3.
In situ hybridization for Epstein-Barr virus encoded small RNA performed elsewhere submitted for review is positive in the large tumor cells and in the smaller reactive lymphocytes.
Per submitted report, flow cytometry performed on the concurrent lymph node was negative for monoclonal B-cell population no aberrant T-cell population.
Link to digital slides: https://bit.ly/3pdQlrE | Case 1