Classic Hodgkin Lymphoma-Syncitial Variant

Lessons From the Friday Unknowns

The patient has diffuse lymphadenopathy and a right axillary lymph node was biopsied.

Histologic sections show lymph node in which the architecture is substantially replaced by lymphoma. The neoplasm has a nodular pattern and dense sclerotic bands are present that course through the lymph node and partially surround some nodules. Capsular fibrosis is also present. The neoplasm is composed of numerous large neoplastic cells with pleomorphic nuclei consistent with lacunar cells in…