EBV+ Polymorphous Post Transplant Lymphoproliferative Disorder

Lessons From the Friday Unknowns

The patient is a 41-year-old female with common variable immunodeficiency (CVID) (agammaglobulinemia).

Histologic sections show core biopsies with a polymorphous infiltrate composed of predominantly small, mature-appearing lymphocytes with scattered admixed larger lymphoid cells (somewhat resembling Hodgkin cells) and histiocytes.