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Follicular Lymphoma with Signet Ring Cell Morphology
Lessons From the Friday Unknowns
Histologic sections show a large lymph node in which the architecture is almost completely replaced by lymphoma. The neoplasm has an almost entirely follicular pattern.
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An unusual morphologic feature is the presence of numerous signet ring cells.
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The grade of the neoplastic follicles is variable and a spectrum is present: — — -There are small numbers of follicles composed almost entirely of centrocytes supporting grade 1:
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As well as other follicles with increased centroblasts supporting grade 3A. However, most of the follicles and the overall grade is best…