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Follicular Lymphoma with Signet Ring Cell Morphology

Siba El Hussein, MD
2 min readDec 19, 2021

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Lessons From the Friday Unknowns

Histologic sections show a large lymph node in which the architecture is almost completely replaced by lymphoma. The neoplasm has an almost entirely follicular pattern.

An unusual morphologic feature is the presence of numerous signet ring cells.

The grade of the neoplastic follicles is variable and a spectrum is present: — — -There are small numbers of follicles composed almost entirely of centrocytes supporting grade 1:

As well as other follicles with increased centroblasts supporting grade 3A. However, most of the follicles and the overall grade is best…

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Siba El Hussein, MD
Siba El Hussein, MD

Written by Siba El Hussein, MD

Hematopathology | Cytopathology | Molecular pathology | Digital pathology | Data science | Machine learning

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