Leukemic Phase of High-Grade CD10-Positive B-Cell Lymphoma

Lessons From the Friday Unknowns

The patient has a history of classi follicular lymphoma.

The current bone marrow specimen shows a high-grade and blastoid lymphoma extensively involving the bone marrow.

Flow cytometry immunophenotypic analysis was performed on this bone marrow and identified an abnormal B-cell population positive for CD10, CD19, CD20, CD22, CD38, CD45 and CD200, and negative for surface immunoglobulin, T-cell antigens and CD56.

In summary, this specimen is involved by a high-grade B-cell lymphoma, CD10-positive, that most likely represents histologic transformation of follicular lymphoma and in leukemic phase. These findings may also represent a high-grade B-cell lymphoma with MYC and BCL2 rearrangements (so-called double hit lymphoma). Correlation with the results of FISH studies will be helpful.

Link to digital slides: https://bit.ly/3WEWJIa | Case 5

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Siba El Hussein, MD

Hematopathology | Cytopathology | Molecular pathology | Digital pathology | Data science | Machine learning