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Mantle Cell Lymphoma
Lessons From the Friday Unknowns
Histologic sections show needle-shaped fragments of lymphoid tissue involved by neoplastic lymphocytic infiltrate in a diffuse pattern.
The lymphoma cells are monotonous small lymphoid cells with irregular nuclear contours, condensed chromatin and scant amount of cytoplasm. Admixed hyalinized vessels are appreciated. No areas of necrosis or increased mitotic figures are noted.
Immunohistochemical studies performed here at MDACC show the neoplastic cells to be positive for PAX5 and cyclinD1, CD3 stains scattered small lymphocytes. Ki67 proliferation rate is 10–20%. AE1/AE3 is negative.
Flow cytometric immunophenotypic studies performed on the concurrent FNA specimen showed an aberrant B-cell population positive for CD5, CD19, CD20, CD22, CD38, CD44, CD45, ROR 1 and surface lambda light chain. The neoplastic cells are negative for CD4, CD 3, CD8, CD10, CD11c, CD23, CD30, CD34, CD56, CD200, and kappa.
In summary, the morphology and immunophenotype support a diagnosis of mantle cell lymphoma.
Link to digital slides: https://bit.ly/3ln1Coq | Slides labeled case 1
