Mantle Cell Lymphoma with Classic & Pleomorphic Features

Lessons From the Friday Unknowns

Histologic sections show lymph node in which the architecture is completely replaced by lymphoma. The neoplasm also extends into perinodal adipose tissue. The neoplasm has a predominantly diffuse pattern but there are also some vaguely nodular areas. Many blood vessels with sclerotic walls are present. In most of the neoplasm the lymphoma cells are small with highly irregular nuclear contours and mitotic figures are relatively infrequent (classic Variant). However, there are some…