Nodular Lymphocyte Predominant Hodgkin Lymphoma

Lessons from the Friday Unknowns

Sections of the right cervical lymph node reveal the presence of vaguely nodular clusters of atypical large lymphoid cells having slightly lobulated nuclei with a vesicular chromatin pattern and distinct nucleoli and moderate pale staining cytoplasm, consistent with LP (L&H) cells.

The atypical large lymphoid cells are surrounded by lymphocytes and scattered histiocytes. A vaguely nodular growth pattern is evident in routinely stained sections.