Reactive Lymphadenitis

Lessons From the Friday Unknowns

Immunoperoxidase stained sections for CD20, PAX 5, CD3, CD5, CD10, CD138, kappa, lambda and CD21 were submitted for review.

CD138 positive plasma cells are mainly within the sinusoids of the lymph node. Kappa and lambda immunostains show a polytypic pattern of positivity of plasma cells. The other immunostains show results compatible with a diagnosis of florid reactive follicular hyperplasia with follicular lysis and prominent monocytoid B-cell hyperplasia with neutrophils in a deep right axillary lymph node.

CD3

CD20

While the changes present in this lymph node are non-specific, they can be seen in lymph nodes of patients having viral-related immune deficiency.

Link to digital slides: https://bit.ly/3Jig7nb | Case 5

Further read:

Morphologic criteria for the differentiation of follicular lymphoma from florid reactive follicular…